Aureobasidin A, also known as AbA, Basifungin, breomycin A, is a cyclic ester peptide antibiotic isolated from the filamentous fungus Aureobasidium Pullulans No. R106. It has a strong anti-fungal ability and is an inhibitor of the inositol phosphorylated ceramide synthase AUR1. It is toxic to yeast even at lower concentrations (0.1-0.5 μg/mL). Species of fungus susceptible to Aureobasidin A include Saccharomyces cerevisiae, Schizosaccharces pombe, Candida glabrata, Aspergillus nidulans, and A. niger.
AbA inhibits the activity of inositol phosphorylamide (IPC) synthase, an essential enzyme for fungalsphingolipid biosynthesis, and interferes with sphingolipid synthesis, thus killing the strain. AUR1 gene from Saccharomyces cerevisiae and AURA gene from Aspergillus aspergillus, homologous genes encoding IPC synthase, are the most studied. Mutations in these genes can make strains resistant to AbA, such as AUR1-C gene.
|Synonym||Aureobasidin A; AbA; Basifungin|
|Molecular weight||1101.42 g/mol|
|Solubility||The powder is soluble in DMSO and methanol (0.5-10 mg/mL); Insoluble in water|
|60231||Aureobasidin A (AbA)||1 mg||5×1 mg||10×1 mg|
The product is shipped with dry ice and can be stored at -15℃ ~ -25℃ for two years. Long-term storage at 4℃ and room temperature is not recommended. Aqueous stock solutions and store at -15℃ ~ -25℃. Avoid repeated freeze-thaw.
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