Anti-DM1 Mouse mAb

Details:

Product description

DM1, also known as maytansine, is a microtubulin inhibitor, potentially conjugated with monoclonal antibodies to form antibody-drug conjugates(ADCs). DM1 as the toxin component of ADCs, exhibits strong anti-tumor activity by inhibiting cell division and inducing apoptosis. 

Specifications

Cat.No.

31901ES60/31901ES80

Size

100 μg/1 mg

Source

Monoclonal anti-DM1 antibody, is produced from a hybridoma which was obtained from a mouse immunized with DM-1.

Buffer

1×PBS, pH7.4.

Type

Monoclonal Antibody

Isotype

IgG1

Host

Mouse

Concentration

1 mg/mL

Purity

94% as determined by reduced SDS-PAGE

97% as determined by non-reduced SDS-PAGE

> 98% as determined by SEC-HPLC

Activity

EC50=8.6 ng/mL by ELISA

Application

ELISA

Storage

This product should be stored at -25~-15℃ for one year, do not freeze.

 Notes

  1. This product is for research use only.
  2. Please operate with lab coats and disposable gloves, for your safety.

 

Data

SDS-PAGE

Anti-DM1 mouse mAb on SDS-PAGE under reduced condition. The purity is 93.4%

Anti-DM1 mouse mAb on SDS-PAGE under non-reduced condition. The purity is 98.0%.

 

SEC-HPLC

The purity of Anti-DM1 mouse mAb is 96.8% as determined by SEC-HPLC.

 

ELISA Data

Dose response curve shows that the EC50 of Anti-DM1 mouse mAb is 8.6 ng/mL.

 

Ver.EN20240725

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