Tetracycline HCl is a broad-spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria, exhibiting activity against a wide range of Gram-positive and Gram-negative bacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some extent to the bacterial 50S ribosomal subunit and may alter the cytoplasmic membrane causing intracellular components to leak from bacterial cells. In cell biology, Tetracycline hydrochloride is commonly used as a selective agent for cells transformed with tetR gene. It is recommended for use in cell culture applications at 5-10 μg/mL.
Features
Applications
Synonyms | Tetracycline hydrochloride, Tetracycline HCl, NCI-c55561, Achromycin V |
CAS# | 64-75-5 |
Formula | C22H24N2O8·HCl |
Molecular Weight | 480.9 |
Appearance | Yellow powder |
Grade | USP |
Potency (Anhydrous) | ≥ 900 mcg/mg |
Solubility | Soluble in water, DMSO and methanol |
Structure |
Components No. | Name | 60212ES25 | 60212ES60 |
60212 | Tetracyclin HCl, USP Grade | 25 g | 100 g |
The product is shipped with dry ice and can be stored at -15℃ ~ -25℃ for two years. Aqueous stock solutions can be stored at -15℃ ~ -25℃ for one year.
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