Ceturegel™ Matrix High Concentration, LDEV-Free is a soluble basement membrane preparation extracted from EHS mouse tumors rich in extracellular matrix proteins. Its main components are laminin, type IV collagen, heparan sulfate proteoglycan (HSPG), and nestin, as well as growth factors such as TGF-beta, EGF, IGF, FGF, tissue plasminogen activator and other growth factors contained in EHS tumors themselves. Ceturegel™ GFR Matrigel is a low-growth factor matrigel obtained after special treatment, which can effectively ensure the needs of some experimental operations that require low-growth factors, such as experiments related to signaling pathways and growth factors. At room temperature, it aggregates to form a biologically active three-dimensional matrix, which simulates the structure, composition, physical properties, and functions of the cell basement membrane in vivo, which is beneficial to the culture and differentiation of cells in vitro. It can be used for cell morphology, biochemical function, migration, Invasion, and gene expression studies.
The three-dimensional culture matrix formed by Matrigel can promote the adherence and differentiation of epithelial cells, hepatocytes, Sertoli cells, melanoma cells, vascular endothelial cells, thyroid cells and hair follicle cells. Ceturegel™ Matrigel can affect gene expression in three-dimensional cultures of murine hepatocytes and human mammary epithelial cells. At the same time, Ceturegel™ Matrigel can be used as a basic scaffold for various tumor cell invasion studies, an essential matrix for in vitro and in vivo studies of angiogenesis, and a three-dimensional scaffold for the growth of transplanted tumor cells in in vivo animal models. Ceturegel™ Matrigel also supports the regeneration of peripheral nerves and the differentiation of bovine fallopian tube epithelial cells.
Ceturegel™ Matrix High Concentration, LDEV-Free Matrigel is a sterile product with a concentration of more than 18 mg/mL, which can meet various experimental requirements, including: in vivo tumorigenesis, angiogenesis research and tumor cell migration, 3D cell research and other applications.
|Product Type||Basement Membrane Matrix|
|Transportation Conditions||Dry Ice Transportation|
|Phenol Red Indicator||Contain|
|Product specifications||5/10 mL|
|Species||EHS Mouse Tumors|
|40187||Ceturegel™ Matrix High Concentration, LDEV-Free||5 mL||10 mL|
Dry ice shipping. -15℃ ~ -25℃ storage, valid for two years.
Figure 1. The application validation of Ceturegel™ Matrix were as shown.
The representative image of HepG2 cell stained with crystal violet after invasion (Figure 1A). The image of 3D culture of HepG2 cell for 4 days (Figure 1B). The representative bright field and fluorescent images of HUVEC cell angiogenesis (Figure 1C)